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Avestin high pressure homogenizers for biotech/pharma​

Martin Birch

Product specialist

E-mail: mbj@aagechristensen.dk

Mobile: +45 40 18 94 98

Rupture of cells etc.

Homogenizers for cell cultivation laboratories and pilot plants

From Avestin we can offer homogenizers to be used primarily for research​. These cover laboratory machines as well as homogenizers for pilot plants and small productions with capacities up to 1,000 l/h.

Test results obtained with the small laboratory models can be upscaled directly to the small production models.

Options for our homogenizers from Avestin include heat exchangers for temperature control and filters/extruders for liposomes.

Avestin's unique high-pressure homogenizers with adjustable homogenizing pressure from 35-2000 bar are extremely suitable for cell rupture (e.g. E. coli and yeast cells), dispersions, liposomes and various emulsions.

The high-pressure homogenizers from Avestin can be delivered with either air-driven motors, where capacity depends on homogenizing pressure, or with electric motors, where capacity does not depend on homogenizing pressure.

Aseptic homogenizers with 6 zones:

  • Homogenizer with four separate steam sterilizable zones, including product zone
  • Possibility of monitoring inlet and outlet process temperature at each sterilized zone

High pressure homogenizers for production

Avestin's standard programme includes 2 production homogenizers for max. 500 l/h and 1000 l/h respectively, but​ can also deliver customized machines for higher capacities.

The EmulsiFlex C500 and C1000 have electric gear motors driven, triplex, high pressure pump designed to minimize the fluctuation of homogenizing pressure. There are no "O"-rings and gaskets in the high pressure product path. All face seals are precision-machined metal to metal or metal to ceramic. As the laboratory models these are adjustable between 30 and 2000 bar.

The production machines are equipped with a dynamic homogenizing valve. The valve can be easily disassembled for cleaning or inspection. Submicron particles or droplets with diameters less than 50nm and extremely narrow size distributions can be achieved.

Both are available with sanitary and electropolished stainless steel heat exchangers to control inlet and outlet temperatures.

Membrane extruders

Avestin's LiposoFast extruders are available in two versions:

  • ​LiposoFast-Basic for either 0.25, 0.5 or 1.0 ml
  • LiposoFast LF-50 for samples between 5 and 50 ml

LiposoFast-Basic

Manual liposome extruders which extrude liposomes through a polycarbonate membrane of defined pore size by means of two small gas-tight syringe. The sample passes through the membrane by pressing the syringes back and forth. The syringes are available in 0.25, 0.5 and 1 ml.

LiposoFast LF-50​

Uses compressed air (up to 41 bar) to force the liposome sample through a polycarbonate membrane of defined pore size and can extrude samples between 5 and 50 ml. This extruder has a stainless steel sample cylinder with a heating jacket for heat-sensitive products. LiposoFast LF-50 is easy to clean and can be autoclaved.

See more information about membrane extruders here

If you wish to learn more

No matter which homogenizer you need, we will find it for you. We will guide you to the right solution. You just have to call us on telephone +45 36 44 24 44 or contact our specialist directly, then we will help you.