Avestin high pressure homogenizers for biotech/pharma​

Rupture of cells etc.

Homogenizers for cell cultivation laboratories and pilot plants

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From Avestin we can offer homogenizers to be used primarily for research​. These cover laboratory machines as well as homogenizers for pilot plants and small productions with capacities up to 1,000 l/h.

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Test results obtained with the small laboratory models can be upscaled directly to the small production models.

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Options for our homogenizers from Avestin include heat exchangers for temperature control and filters/extruders for liposomes.

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Avestin's unique high-pressure homogenizers with adjustable homogenizing pressure from 35-2000 bar are extremely suitable for cell rupture (e.g. E. coli and yeast cells), dispersions, liposomes and various emulsions.

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The high-pressure homogenizers from Avestin can be delivered with either air-driven motors, where capacity depends on homogenizing pressure, or with electric motors, where capacity does not depend on homogenizing pressure.

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Aseptic homogenizers with 6 zones:

• Homogenizer with four separate steam sterilizable zones, including product zone
• Possibility of monitoring inlet and outlet process temperature at each sterilized zone

High pressure homogenizers for production

Avestin's standard programme includes 2 production homogenizers for max. 500 l/h and 1000 l/h respectively, but​ can also deliver customized machines for higher capacities.

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The EmulsiFlex C500 and C1000 have electric gear motors driven, triplex, high pressure pump designed to minimize the fluctuation of homogenizing pressure. There are no "O"-rings and gaskets in the high pressure product path. All face seals are precision-machined metal to metal or metal to ceramic. As the laboratory models these are adjustable between 30 and 2000 bar.

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The production machines are equipped with a dynamic homogenizing valve. The valve can be easily disassembled for cleaning or inspection. Submicron particles or droplets with diameters less than 50nm and extremely narrow size distributions can be achieved.

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Both are available with sanitary and electropolished stainless steel heat exchangers to control inlet and outlet temperatures.

Membrane extruders

Avestin's LiposoFast extruders are available in two versions:

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• ​LiposoFast-Basic for either 0.25, 0.5 or 1.0 ml
• LiposoFast LF-50 for samples between 5 and 50 ml

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LiposoFast-Basic

Manual liposome extruders which extrude liposomes through a polycarbonate membrane of defined pore size by means of two small gas-tight syringe. The sample passes through the membrane by pressing the syringes back and forth. The syringes are available in 0.25, 0.5 and 1 ml.

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LiposoFast LF-50​

Uses compressed air (up to 41 bar) to force the liposome sample through a polycarbonate membrane of defined pore size and can extrude samples between 5 and 50 ml. This extruder has a stainless steel sample cylinder with a heating jacket for heat-sensitive products. LiposoFast LF-50 is easy to clean and can be autoclaved.

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​See more information about membrane extruders here